Does ProMind Complex Work? Independent Review

Does ProMind Complex work? reaDementia investigates the validity of the company’s claims.

Identifying a supplement that offers benefit to people, either with dementia or seeking to prevent dementia, is a formidable task. There are many supplements marketed online and in stores- perhaps too many! investigated several products that we felt had the ingredients and integrity to be worthy for our audience to consider. One product, ProMind Complex, ticked many of the boxes.

We investigated the creator’s claims that his product benefits people with cognitive decline. Our research (looking into clinical studies) does show strong support of several of the ingredients in the ProMind Complex formulation.

We also see plausible reason in the creator’s approach to removing toxic dental bacteria, a major contributor to plaque build-up in the brain- leading to brain cell damage. Our investigation identified research that supports his reasoning.

Brain Food Supplement ProMind Complex

A Brief Summary of ProMind Complex

Category: Anti-memory Loss Supplement

Ingredients: Huperzine, Vinpocetine, Phosphatidylserine, St. John’s Wort, N-Acetyl-L-Carnitine, Ginkgo Biloba Leaf, Bacopa Monnieri, and vitamins.

Key Features: FDA Approved guidelines; GMP Certified; Non-habit forming; 100% natural; Non-GMO; Gluten-free; 3rd party audited.

Does ProMind Complex Work?Benefits
• Helps remove harmful plaque within the brain
• Prevent memory loss
• Reduces anxiety and depression
• Assists learning abilities
• Helps with focus and concentration
• Removes brain fog and inflammation
• Supports cognitive performance
• Reduces gum inflammation
• Enhances the clarity of mind
• Improves blood supply to the brain
• Increases oxygen and nutrients to brain cells

Price: $49 to $69 bottle (dependent on quantity purchased). Equates to $1.63/day to $2.30/day Check Price

Formula: Capsules

Dosage: 1 capsules/day for adults

Made in: USA

Guarantee: 60 days money-back guarantee

Availability: USA, UK, Australia, New Zealand, Canada

Where to Buy?


What is ProMind Complex?

ProMind Complex is an all-natural supplement that aims to improve the brain’s cognitive functioning — including thinking, memory, executive function, creativity, and motivation. Carl Henderson and his team claim to have provided a solution that is allegedly backed by extensive research.

According to Dr. Henderson, ProMind Complex is formulated using premium ingredients consisting of herbs, other plants, and amino acids, in carefully measured quantities to help enhance cognitive abilities.

Who Developed ProMind Complex?

Formulated by Carl Henderson, a Psychology doctor from Texas. He, along with Dr. Jack Lane, combined herbs, vitamins and essential amino acids to arrive at a solution for prevention of dementia.


ProMind Complex Ingredients

The supplement facts label indicates 1 capsule has these ingredients and dosages

St. John's Wort250 mg
Glutamine150 mg
Phosphatidylserine125 mg
Bacopa Monnieri120 mg
Ginkgo50 mg
N-Acetyl-L-Caritine HCL50 mg
Vinpocetine2 mg
Huperzine A10 mcg

Other ingredients listed are gelatine, microcrystalline cellulose magnesium stearate, and silicon dioxide.


ProMind Complex Ingredients Discussed:

ReaDementia examined the ingredients’ list to look at how each natural ingredient benefits cognitive functioning. We also identified some of the clinical studies, on each ingredient, that support/not support Dr. Carl Henderson’s claims.


periwinkle brain healthA compound from the Periwinkle plant that is utilized as a cognitive shield and anti-aging agent.

The ProMind Complex company says this compound repairs damaged brain cells and opens blood vessels in the brain allowing for oxygen to flood the brain, and this helps repair nerve cells.

Research shows vinpocetine increases blood flow to the brain– supporting what the company claims.

Another benefit identified is with relieving stress helping a person feel relaxed.

In a study, Vinpocetine has also been shown to improve memory after 2 days in healthy people at a dosage of 40 mg, three times a day. ProMind Complex provides 2mg of Vinpocetine per capsule, once a day. This is well below the dosage used in the study.

Numerous studies looking at Vinpocetine and the benefits of increased blood circulation and metabolism in the brain have been conducted. Although the studies are promising, the evidence for beneficial effect of vinpocetine on people with dementia is inconclusive.

Vinpocetine has been sold by prescription under the name Cavinton.

Huperzine A

huperzine aThis herb derived from Chinese club moss Huperzia serrata, it is listed in’s top 10 list of beneficial herbs.

The plant has powerful antibacterial properties that help with fighting harmful bacteria on the brain’s surface. It provides a protective shield (coating), blocking out toxins and bacterial infections.

According to, Huperzine A behaves as a cholinesterase inhibitor, thus improving the levels of neurotransmitters in the brain.

Small early studies suggest that the herb might improve memory and protect nerve cells, which could reduce cognitive decline associated with Alzheimer’s.

Ginkgo Biloba

Ginkgo BilobaA tree of native China and also listed in our top 10 list of herbs that benefit dementia.

Due to its ability to aid blood flow, this compound assists neurotransmitters in the brain, which play a role with stress and fatigue. The herb also helps in considerably lowering the rate of periodontal disease pathogens (dental bacteria leading to toxins that are the cause of damaging brain plaque- explained further into this review).

In clinical trials, there is promising evidence of ginkgo supporting brain health in Alzheimer’s disease, cerebrovascular disease, mild cognitive impairment, and vascular disease. In addition, ginkgo gives benefit to several other bodily systems.


Not an herb, however an excellent ingredient that works directly with memory and analytical skills.

A healthy human body makes adequate L-Carnitine, and it can also be gained from eating animal products.

L-caritine helps with speedy and effective learning, having a direct effect on our analytical reasoning and concentration building skills.

Together with its memory-boosting ability, L-Carnitine also benefits with insomnia issues, helping people achieve higher levels of energy and mental alertness.

Clinical trials suggest that supplements of acetyl-L-carnitine may enhance mental function and decrease deterioration in older adults with mild cognitive impairment and Alzheimer’s disease.


An amino acid found in a variety of foods known for helping with brain cell membranes. It works like a wall that safeguards the brain membrane against harmful elements. As a result, it aids memory retention, memory alertness and brain function.

The human body does synthesise phosphatidylserine; however, with older people supplementation seems to improve memory and cognitive capacity.

Studies do support this claim: For example; in a 2010 study published in the Journal of Clinical Biochemistry and Nutrition, 78 elderly people with mild cognitive impairment took part.

Participants supplemented with phosphatidylserine derived from soy beans were found to have experienced a significant improvement in memory over a 6 months trial period.

St. John’s Wort

St. Johns WortWhen used over time it is known to scrape the hardened plaque (explained later in review) out of your brain and enhances supply of blood flow to your brain, aiding active brain cell communication.

In addition, St. John’s Wort helps keep the brain from using up neurotransmitters like serotonin, GABA, dopamine, and norepinephrine. As a result, the neurotransmitters are more effectively utilized in the brain. This can work as an antidepressant giving an overall feel-good effect in the brain.

This peer reviewed animal study using mice using St. John’s wort as treatment to reduced Alzheimer’s disease pathology, supports the reduction of plaque reasoning.

Bacopa Monnieri

Bacopa MonnieriIncluded in the formula for its powerful memory building nutrients helping those with memory loss.

Bacopa Monnieri is known in Ayurvedic medicine for treating anxiety, epilepsy, and forgetfulness.

Studies demonstrate immense potential in the improvement of cognitive disorders, as well as reduction of oxidative damage, NT modulation, and cognitive enhancement in healthy people.

Research on Bacopa Monnieri is still in its infancy, but early results are very promising.


An amino acid known to relieve stress, depression, and anxiety. Tyrosine is available naturally in many foods such as meats, soy, almonds, avocados and seeds.


Retailer of the Product

BuyGoods is the authorized retailer of this product, which is a registered trademark of BuyGoods Inc., a Delaware-based corporation.

The marketing campaign of ProMind Complex is managed by ClickBank, a Delaware-based company that has years of experience in affiliate marketing.

How Does ProMind Complex Work?

Dr. Carl Henderson and his team use a step-by-step approach to improving cognitive function.

1. Firstly, this is done by taking care of the periodontal disease pathogens:

Clearing the dental nerve bacteria. This oral bacteria can get in the brain. Once there, they excrete protein and enzyme by-products that lead to damaging the brain’s nerve cells.

Diminishing the plaque-forming bacteria and that interfere with memory loss.

2. Once the disease-causing bacteria has been lessened, the next step is restoring blood-flow to the brain– supplying essential oxygen and nutrients for cells.

3. Lastly, an approach to repairing damaged brain cells is applied, followed by bullet-proofing the brain, protecting it from future damage.

The herbal formulation works on the toxic plaque growth, which appears to be the main cause of cognitive problems, such as age-linked memory loss.

According to Healthcare Business Today, ProMind Complex has anti-inflammatory ingredients that also help with cerebral metabolism and effective functioning of overall brain health.

Brain Plaque link to Alzheimer's disease

The Link Between Dental Bacteria and Dementia

The makers of ProMind Complex point to dental bacteria as the basis of memory problems like dementia and Alzheimer’s Disease. This bacteria (called Porphyromonas gingivalis) cause problems when it travels from the mouth and gums up into the brain.

The bacteria generate a toxin known as gingipains, which leads to memory impairment, serious memory loss, and Alzheimer’s.

By using their simple breath test – smell your breath in the morning and have smelly breath – you can tell if you have the bacteria and are at risk of having cognitive impairment in the future.

Does ProMind Complex work? Are the makers of this supplement, correct in saying? We found research that does support their claim, suggesting that there is a link between dental bacteria and dementia.

Strong-Risk-Factor to Alzheimer’s Disease Being Dental Bacteria- Research

Researchers have discovered the gingipains toxin is present in over 90% of people with Alzheimer’s.

Researchers infected brain stem cells with Porphyromonas gingivalis, a dental bacteria which makes gingipains.

They found that the gingipains toxin caused brain cells to die and reduced tau protein– essential for helping neurons stay healthy.

These dental bacteria also increased inflammation– another risk factor for dementia and other diseases. This has led some researchers to call Porphyromonas gingivalis a “strong risk factor” for Alzheimer’s disease.

It’s not substantiated if this is the case for those who have infrequent problems with remembering.

These toxin causing dental bacteria have also been found in artery-clogging plaque. This indicates a link with heart disease as well.

Amyloid plaques in Alzheimer's disease

ProMind Complex Research- Does ProMind Complex Work?

Is there any research that supports ProMind Complex being beneficial to cognitive function? We found that there is, and there isn’t.

While there appears to be no research specifically on ProMind Complex, there is research on the ingredients it uses (as we have already outlined).

The creator’s premise behind the key ingredients is that they work best together, rather than by themselves. This is described as the entourage effect. While this appears to be the case, there is no evidence that the combination of ingredients in ProMind Complex has an entourage effect.

How Long Until Results Are Seen?

The company says fairly soon, although this will vary from person to person and the memory problems they may have. Our advice is to remember improvements in health take time. No supplement works overnight, especially when it comes to getting your memory back. The company recommends giving ProMind at least 60 days to allow the nutrients time to flood your system.


ProMind Complex Safety

The company’s website says all the ingredients used in the formula have been thoroughly tested and delivered in the right quantity and ratio for optimal efficiency, whilst ensuring safety.

The Food and Drug Administration (FDA) does not endorse dietary supplements. What it does do is regulate supplements. Regulation and approval are different. Usually, supplement companies do not need to seek approval from the FDA before selling products to the public.

Having clarified that, ProMind complex formula has been formed under the FDA-approved guidelines. The company’s website states that certified goods manufacturing practices have been met to the highest standard.

Independent third-party testing is conducted to uphold the dosage, potency, and of the product. ProMind Complex is non-GMO, vegan-friendly and gluten-free.

ProMind Complex Side Effects & Adverse Reactions

While there are no serious side effects known from taking this supplement, there are a few precautions.

The company instructs not to exceed the recommended dosage of one capsule/day. They also advise those with bleeding disorders, people taking blood thinners, and those on antidepressant medications (such as MAO inhibitors) to consult to their doctor before starting on the supplement.

Other considerations:

  • Store in a cool, dry place.
  • If the safety seal is broken, do not consume.
  • Avoid if pregnant or breastfeeding.
  • The ingredient, St. John’s Wort, may have drug interactions. This may include birth control pills. If you take medications, consult with your doctor.
  • Some ingredients may thin the blood. Stop taking the supplement at least 2 weeks prior to having surgery- including dental surgery.
  • The supplement is not intended for children.
  • For those with allergies, the product is manufactured is made in a facility that may also process milk, soy wheat eggs, peanuts, tree nuts, and shellfish.


What Are the Benefits of ProMind Complex?

1. An instant memory boost, something that allows people to act more rationally in day-to-day life.

2. Helps with keeping age-related cognitive concerns at bay, therefore helping people with enhanced brain functioning.

3. A memory-strengthening supplement, refilling the brain with memory and energy.

4. Helps maximise focus and sustain concentration.

5. Helps reclaim memory power and boost brain performance.

6. Assists with learning, whilst keeping mental fatigue at bay.

7. Helps eliminate bacterial plaque, whilst strengthening and rebuilding brain cells.

8. Alleviates anxiety and negative feelings.

9. Aids in releasing the ‘feel good’ hormone in the brain.


This product contains 30 capsules in each bottle. The company advises that adults take one capsule a day after a meal.


ProMind Complex GuaranteeThe company gives a 60-day 100% money-back guarantee– valid on empty bottles too. This guarantee period begins when the product is shipped, not when it arrives.

Keep in mind, sixty days may not be enough time to tell if the product is helping you with memory and cognitive problems. The company suggests giving it at least two months to work.

How To Get A Refund

Does ProMind Complex work? If you are not satisfied with the product, return the bottles to this address: 37 Inverness Drive East, Suite 100, Englewood, Colorado, 80112.

Remember to send all opened and unopened bottles back within the 60 days.

The company will send an email when they have received your returned bottles. If you have questions/concerns you can contact the company at

Packaging Options

ProMind Complex can be purchased in a single bottle, or in multiple bottles. The company provides a better price when you buy multiple bottles.

Shipping Information

When ordering within USA, shipping is free. The shipping rate for other countries is set at $15.95. The company does ship to Canada, UK and Ireland, Australia and New Zealand.

Once your order has been placed, you will receive an email (within 60 hours) with tracking information on your package.

US orders arrive within 5-7 days. Orders sent to other countries may take 10-15 working days.

Where to Buy ProMind Complex

ProMind Complex is only sold by the company itself at their official website. This is done to protect the product from copycat products and third-party involvement. The product cannot be purchased from retail stores or other online stores.

When reviewing this product, we found other online stores (such as Amazon) selling a supplement with the same name as ProMind Complex. On closer inspection it appears that these products are made by different companies and their ingredients are not the same.

Who Manufactures ProMind Complex?

The company is called The ProMind Complex, Inc, a sole proprietorship that was started in 2020. The Official website is

ProMind Complex options


Our Verdict

Although there are no clinical studies yet conducted to confirm the effectiveness of ProMind Complex, we are encouraged by several of the ingredients used in the formulation.

There is sufficient research-based evidence to support that these ingredients do help people with cognitive decline (in particular bacopa and huperzine). Whilst this is encouraging, there are also ingredients listed where their effectiveness cannot be substantiated.

The supplement may not contain sufficient levels of certain ingredients to be fully effective. For example, in a study, Vinpocetine had an effect in 2 days at 40mg/day, yet ProMind Complex has only a small amount (2mg) of Vinpocetine per capsule.

We accept the creators’ explanation that dental bacteria are a root cause of plaque build-up in the brain, causing cell decline. This is well supported by research. The ingredients specifically selected by the creators of ProMind Complex were included in the formula to help reduce gingipains toxin caused by dental bacteria. We accept St John’s Wort being a key ingredient that helps reduce plaque.

The step-by-step approach using a combination of natural ingredients working in synergy is plausible; firstly, taking out the toxins that have caused the plaque build-up that damaged brain cells, then replenishing and repairing brain cell function by improving blood flow.

Does ProMind Complex work? Although ProMind Complex demonstrates many of the attributes to help people with dementia, we don’t see it necessarily working overnight. In our view, it is likely to take several months to notice any real difference. This will vary from person to person depending on factors specific to them, such as how severe their condition is and what they are seeking help with.

We see no risk in giving the supplement a try. If you’re someone who is noticing forgetfulness, inability to focus and concentrate, and feeling a lack of motivation; ProMind Complex does have the attributes to make a difference.

Does ProMind Complex work? If you feel it is not helping, then utilize the 60-day money back guarantee to get a refund.


ProMind Complex Pros & Cons


  • Ingredients make sense
  • Several ingredients validated by research
  • Tackles root cause of brain cell damage- removal of plaque formation
  • 60- day money-back guarantee
  • Undergone rigorous testing for safety and efficacy
  • Additional benefits: heart health, blood flow, well being
  • Easy to purchase
  • Costs as little as $1.63/day


  • No research on supplement itself
  • Some ingredients’ research is preliminary
  • May take time for a noticeable result
  • Only available from the company’s web site
  • Additional delivery costs for international orders
  • Copycat inferior products found in other stores

ProMind Complex Price

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